The vast majority of Western medicine tablet particles must be objective, granulation, tablet, which is determined by the material properties. Made of particles, increase the flowability and compressibility. Liquidity is often static angle, angle of repose fluidity is good, otherwise the opposite. Compressible most simple measures were pressed into tablets pressure required for a certain hardness, if the required pressure is low, pressure may be applied, or, if the hardness is under certain pressure can be compressed into a compressed tablet hardness. Swing granulator granule preparation is a key operation law a related digital board and the success of the tablet quality is good or bad granules.
Swing objective particle machine particles specifically as follows.
(1) increase the liquidity of the material: liquidity fine powder is poor, cannot smoothly from the feed hopper of die hole, less fluctuation, difference of tablet weight increased, but also the impact of tablets and granulation content increase liquidity. Drug powder of angle of repose is generally about 65 degrees, generally about 45 degrees angle of repose of the particles, so the particle good fluidity powder.
(2) reduced to adsorption and save the air sheet loose crack powder reduced: fine powder is larger than the surface area, adsorption in the air content in storage, when the punch is pressurized, powder part of the air can escape timely digital plate pressure, when the pressure is removed, the tablet, the internal air expansion crack caused by loose tablets.
(3) to avoid the powder layer: the original factory parts powder density prescription tablet of several different types of process, due to vibration machine, sink so heavy, so that the light floating stratification is not allowed content.
(4) to avoid dust fine: fine dust, surface adhere to the punch or die wall, very easy to cause the sticking phenomenon
All medicinal powder mixture material granulation of different herbs powder granulation method with the appropriate soft material, method of adhesive or wetting agent made by extruding and granulating sieve (1). Adhesive or wetting agent must be in accordance with the powder properties of choice, if the powder contains more minerals, strong adhesive adhesive, fiber and water composition should be used such as syrup, honey, caramel, or in combination with starch; prescription containing a viscous component, optional water, alcohol dampening.
This method is suitable for small doses of toxic drugs, almost no fiber powder production. Such as ginseng tablets Anwei tablets, does not apply to general medicine or excessive dosage. This method is simple, rapid, economic advantage, but must pay attention to powder disinfection tablet, conform to the hygiene standards. The crude extracts of some medicinal powder made of thick extract mixed granulation prescription medicines, the other part is crushed into fine powder of herbs, two viscous mixture can be directly made of soft materials, particle systems. If the, after mixing with adhesive or cohesive wetting granulation amount. A mixture of ropy should be things granulation too difficult, pressure test spots particles, medicinal powder, crude extract of pitting drying, crushing into fine powder, add operation, made of soft material with moisturizing agent particle system. The wider application of this method, applies the particle. Such as Yuanhuzhitong tablets, bezoar antidotal tablet. The biggest advantage of this method is the thick extract powder in addition to have a certain therapeutic effect, thick extract from the binder, and the powder pharmaceutical disintegrating agent, powder granulation and save attachments, simple operation.
Swing the soft material to squeeze through the mesh screen based on the principle of the extrusion granulating machine, so as to achieve the purpose of producing mechanical granulation. Due to the soft material granulation, so we need medicine process. Soft material preparation complete disconnection, and granulation processes are not coherent, and energy efficiency ratio difference, the production capacity is not high, materials loss. Now the equipment used are rarely. Now mostly to shear granulator. |
Swing and pellet granulator in medicine industry purpose